Figure 1 BET inhibition is synthetic lethal to OXPHOS blockage in liver cancer. Left: GDH1-dependent glutamine metabolic remodeling upon BET inhibition. Right: “Synthetic lethality” targeting OXPHOS ...
Mitochondria are known as the body’s “energy factories,” and their function is essential for life. Inside mitochondria, a set of complexes called the oxidative phosphorylation (OxPhos) system ...
Using stem cell-derived artificial organelles to improve neural oxidative phosphorylation imbalances
Scientists from The First Affiliated Hospital of Dalian Medical University have developed a novel bioengineered system using membrane self-assembly to create neural stem cell-derived oxidative ...
Sarcomas are generally classified into soft tissue sarcomas, such as fibrosarcoma, and bone sarcomas such as chondrosarcoma, which are rare cancers in adults accounting for about 1% of all cancer ...
New findings in mice suggest it’s possible to prevent organ damage from COVID-19 with an antioxidant enzyme that protects a cell’s mitochondria without the risk of resistance. The study that led to ...
Researchers from Sichuan University synthesized new pyrazole amides based on the previously described NADH-ubiquinone oxidoreductase (complex I, CI) inhibitor IACS-010759. Subsequent optimization ...
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